ncRNA name | hsa-miR-125b |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB tissue; RB cell lines HXO-RB44, Y79 and SO-RB50; human RPE cell line ARPE-19 |
Methods | RT-PCR, cell migration and invasion assay, luciferase reporter assay, Western blot |
Expression pattern | up-regulated |
Functional description | miR-125b is a suppressor gene miRNA that can promote RB cell proliferation and migration by downregulating the suppressor gene DRAM2, indicating that miR-125b may represent a new potential diagnostic and therapeutic target for RB treatment. |
PubMed ID | 27527066 |
Year | 2016 |
Title | MicroRNA-125b promotes tumor growth and suppresses apoptosis by targeting DRAM2 in retinoblastoma. |
Drug-related ncRNA | NO |
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